Study the Role of Interleukin-4, Interleukin-17 and Interleukin-35 in Diagnosis and Prognosis of Preeclampsia in Egyptian Patients

A.M.Agha1, A.M.Abdelrahman1, A.M.Thabet1, B.E.Sakr2 and H.M.Ahmed1"


Toxemia is a genuine entanglement of pregnancy, which is the reason for 60,000 maternal passings every year around the world. Notwithstanding the notable maternal hazard factors, for example, hypertension, diabetes mellitus, antiphospholipid neutralizer condition, heftiness, maturing, and various pregnancies, ongoing investigations have distinguished the job of hereditary and immunological elements in the pathogenesis of toxemia. PE could prompt maternal and pre-birth dismalness. Imbalanced cytokine arrange and modified degrees of a few fiery and calming cytokines have been accounted for in PE The examination intended to evaluate the serum levels of IL-4, IL-17 and IL-35 in toxemia patients well as in normotensive pregnant women.Blood tests were gathered from 25 toxemia patients and 15 normotensive pregnant ladies. Serum levels of IL-4, IL-17 and IL-35 in totally examined bunches were controlled by an immunoenzyrnatic test. The outcomes indicated higher groupings of IL-17 in PE and huge contrast between PE cases and control gathering and no noteworthy distinction in IL4 and IL35. A critical positive relationship was found between serum IL-17 and negative connection with maternal age, gravidity state, SBP and DBP.

Key words

Interleukin-4, Interleukin-17,Interleukin-35, Diagnosis and Prognosis of Preeclampsia