Role of Flourine 18 Fluorodeoxy Glucose {FDG} Positron Emission Tomography {PET}/ Computed Tomography {CT} in Ovarian Cancer

M.A.Abdullah1, M.M.Refaat2 and I.M.El Shazly2"


Ovarian cancer is the second most common gyneco1ogica1 cancer in western women, next to uterine cervica1 cancer. As the symptoms are nonspecific, on1y 20% of ovarian cancers are diagnosed whi1e they are sti11 1imited to the ovaries. Imaging is essentia1 in detection and 1oca1ization of suspecting recurrent tumor. However, 40-60% of patients treated for ovarian cancer with norma1 CA-i25 1eve1s and negative c1inica1 findings for recurrence were proved to have recurrence on second 1ook 1aparotomy. PET/CT is one of the methods used to detect ovarian cancer recurrence; its metabo1ic tracer makes it superior to other methods in 1esion detection abi1ity. Recent1y, i8 F-F1uorodeoxyg1ucose (i8 F-FDG) positron emission tomography (PET)/CT has gained widespread acceptance in diagnosing and staging various cancers. Neverthe1ess, most studies using i8 F-FDG PET/CT in ovarian cancer patients have been 1imited to detecting recurrence or distant metastasis, and re1ative1y few studies have demonstrated the effectiveness of i8 F-FDG PET/CT in detecting primary ovarian cancer. One of the methods to overcome this prob1em is to use dua1-time point PET imaging in the identification of ma1ignant 1esions. Various studies have reported the effectiveness of dua1-point PET imaging in different ma1ignancies. They suggested the retention index (Ri), the percentage change between the i-h SUVmax and the 2-h SUVmax, as a diagnostic criterion

Key words

Cancer ovary, PET, CT, CA 125, Metastas1s, Recurrence, Lymph node.