IL17RA Gene polymorphism in Alopecia Areata in an Egyption sample

E.M.Sanad1, R.M.Salem1, H.M.Ali2 and S.N.Elshafee1"


Alopecia areata is the demonstration of autoimmune attack against hair follicles which causes an inflammatory condition of the hair follicle. The autoimmunity is the defect in immune tolerance, resulting in the production and proliferation of autoreactive T-cells which expresses both interleukin (IL)-17A and IL-17F, both can signal via the IL-17 receptor A. To investigate the significance of IL17RA gene polymorphism in the susceptibility of alopecia areata in Egyption population. This study was carried out in Benha University, Dermatology, Venereology & Andrology Department . We conducted a case-control association study of 100 alopecia areata patients and 100 matched healthy controls. Allele frequency of a single nucleotide polymorphim in IL17RA gene was studied using Real Time PCR technique. The A allele and AA genotype of the SNP(rs879577) of IL17RA gene incresase the risk of alopecia areata (p<0.001) significantly. IL17RA gene polymorphism might contribute to the increased susceptibility to alopecia areata in Egyption population.

Key words

Alopecia areata, Interleukin-17 receptors A, Single nucleotide polymorphism.