Serum Level of Periostin and Cardiac Function in Patients with Psorasis

M.S.El Bahrawy1, S.I.Farg2, O.S.El-Shimi3, A.I.Mustafa3, A.A.El-Taweel4"


Psoriasis is a common chronic immune mediated relapsing and remitting, inflammatory skin diseases causing significant impairment of quality of life, at least to the same extent as other major medical diseases. About 2% of the population in Europe and the United States are affected by psoriasis. the present work aim to asses serum level of periostin in psoriatic patients, in an attempt to elucidate its role in the disease pathogenesis in psoriatic patient. fifty adult patients with psoriasis vulgaris (PV) as a disease control and30 healthy controls were determined their serum level of periostin using An enzyme-linked immunosorbent assay. serum levels of periostin were significantly increased in psoriatic patients, with a significant positive correlation to the disease severity when compared to the healthy controls. In conclusion, periostin may play a role in the pathogenesis of PV.

Key words

Psoriasis vulgaris, Periostin.