Role of Transcranial Doppler Assessment of Cerebral Blood Flow in Neonatal Sepsis

M.M.Refaat, A.A.Torky and D.A.Gouda"


Neonatal sepsis is one of the leading causes of morbidity and mortality among term and preterm infants worldwide.assessment of the changes in cerebral blood flow velocity [CBFV] in cases of the neonatal sepsis.This study including 100 infants. 60neonates are diagnosed with neonatal sepsis [Sepsis group].while the other 40 neonates with no signs of neonatal sepsis [Control group]. Trans-cranial Doppler [TCD] was carried out for assessment of blood flow velocity in the anterior [ACA] and middle cerebral arteries [MCA] Peak systolic velocity [PSV], end diastolic velocity [EDV], and resistive index [RI] were measured.RI and PI were significantly decreased, with mean RI 0.56in MCA & Median RI in ACA 0.59 & Median PI 0.98; 0.98 in MCA & ACA respectively in the case group, while with a mean RI 0.75 in MCA & Median RI 0.72 in ACA respectively & Median PI1.35; 1.27 in MCA & ACA respectively .Whereas the Peak systolic velocity was increased with a mean of 69.07 in MCA & Median of 66.4 in ACA respectively in case group & mean of 50.22; in MCA & Median of 44.0 in ACA in control group with p value <0.001 in MCA & ACA respectively. neonatal sepsis causes increase in Peak systolic velocity & decrease in the Resistive & Pulsatility index thus causing increase in the cerebral blood flow, which in turn showed increased incidence in Intraventricular hemorrhage .

Key words

Neonatal sepsis, Cerebral blood flow [CBF], Trans-cranial Doppler [TCD].