Renal Protective Effect of Cardamom Against Nephrotoxicity Induced by Gentamicin in Rats

A.Elkomy, M.Aboubakr and N.El-sawaf"
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Abstract


This study was conducted to evaluate the renal protective effect of cardamom against experimentally-induced gentamicin toxicity in rats. Forty adult male Wistar albino rats were randomly grouped into four groups (each of 10 rats). Rats in group (1) were orally administered saline (the vehicle) daily for 8 consecutive days and severed as control group. Group 2: were given gentamicin (80 mg/kg. b.wt. i.p.) daily for 8 consecutive days. Group 3: were given gentamicin (80 mg/kg. b.wt. i.p.) daily for 8 consecutive days, then cardamom extract (100 mg/kg. b.wt. p.o.) daily from 9th to 21th days. Group 4: were given gentamicin (80 mg/kg. b.wt. i.p.) daily for 8 consecutive days, then cardamom extract (200 mg/kg. b.wt. p.o.) daily from 9th to 21th days. Gentamicin-treated rats showed significant renal damage as it the creatinine, urea, glucose and total protein showed a significant decrease. While in groups (gentamicin+cardamom 100 mg/kg & gentamicin+cardamom 200 mg/kg), showed significant protection to rat’s kidney from structural and functional changes associated with gentamicin. Gentamicin which induced nephrotoxicity can be prevented by co-administration with cardamom.

Key words


Cardamom , Gentamicin, Nephrotoxicity.