The Hypolipidemic Effect of Ginger and Fenugreek in Rats

K.M.Fararh, O.M.Ali, M.A.Galalah"


Hyperlipidemia is one of the most important risk factors for liver diseases and atherosclerosis. This study was used to evaluate the effect of hypolipidemic agents on some biochemical parameters such as total lipids, total cholesterol, triglycerides, low density lipoproteins (LDL), very low density lipoproteins (VLDL), high density lipoproteins (HDL), lecithin cholesterol acyltransferase enzyme (LCAT), apolipoprotein B (ApoB), phospholipids and serum glucose level. Animals were divided into four groups (1st group was left without treatment as control, while 2nd group was hyperlipidemia group; fed with high fat diet [HFD] for 9 weeks. Other 2 groups were treatment groups as [HFD + ginger 400 mg/kg], [HFD + fenugreek extract 200 mg/kg] daily orally for 5 weeks. Blood samples and tissue specimens from liver were collected after 6 and 9 weeks. Results of treatment revealed significant decrease in lipid parameters and glucose level while obtained increase in HDL. Therefore, the differences of hypolipidemic agents such as ginger and fenugreek were estimated by evaluation the different biochemical parameters.

Key words

ApoB, Fenugreek , Ginger, Hyperlipidemia, LCAT.