Biochemical Effect of Beta-blockers on Thyroid Function and Lipid Metabolism in Experimentally Induced Hyperlipidemia in Rats
O.M.Abdel-Hamied1, A.A.Nafeaa2 and H.A.Ghoneimy3"
The present study was employed to investigate the biochemical effects of Propranolol or Atenolol adminstration as non-selective or selective beta-blockers, respectivly on thyroid functions and lipid metabolism. Forty male albino rats were assigned into two groups (the first group contained 10 rats fed on normal diet while the second group contained 30 rats used for induction of hyperlipidemia. Then the second group was divided into 3 sub groups (each of 10 rats). Sub group 1: act as positive control hyperlpidemic rats, sub group 2: adminstrated propranolol orally while sub group 3: adminstrated atenolol orally. Then blood samples were collected after 3 and 5 weeks from the drugs adminstration. Serum was collected for estimation of Triiodothyronine (T3), Tetraiodothyronine (T4), Thyroid Stimulating Hormone (TSH), Total Cholesterol, High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein-Cholesterol (LDL-C), Very Low Density Lipoprotein-Cholesterol (VLDL), Triacyclglycerols (TAG), Phospholipids, Leptin, Lipoprotein lipase (LPL), Lactate dehydrogenase (LDH), Creatine Kinase (CK) and Creatine Kinase-MP (CK-MP) as isoenzyme, Calcium and phosphorous. The obtained results revealed that, propranolol has more biochemical effect in significant decreasing (T3) than atenolol with non-significant decrease in serum (T4), both of propranolol and atenolol has no effects on TSH, cholesterol. Both of propranolol and atenolol has the same effects in significant decreasing HDL and lipase activity. Propranolol has more biochemical effect in significant increasing TAG, VLDL, phospholipids, LDH than Atenolol. Both of propranolol and atenolol has the same effect in significant increasing serum leptin.
Atenolol, Cardiac markers, Hyperlipidemia, Lipid profile, Propranolol, Thyroid hormones.